Article
Rapid diagnosis of Miller-Dieker syndrome and isolated lissencephaly sequence by the polymerase chain reaction.
Human genetics - 1 Oct 1990
Batanian J R, Ledbetter S A, Wolff R K, Nakamura Y, White R, Dobyns W B, Ledbetter D H
Abstract excerpt
Probe YNZ22 (D17S5) is a highly polymorphic, variable number tandem repeat (VNTR) marker previously shown to be deleted in all patients with the Miller-Dieker syndrome (MDS) but not in patients with isolated lissencephaly sequence (ILS). Primers were constructed to the unique sequence flanking th...
Topics
- Abnormalities, Multiple
- Alleles
- Base Sequence
- Blotting, Southern
- Brain
- Brain Diseases
- Chromosomes, Human, Pair 17
- DNA
- Female
- Gene Amplification
- Gene Frequency
- Genetic Markers
- Humans
- Male
- Molecular Sequence Data
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Repetitive Sequences, Nucleic Acid