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Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

26 Oct 2011

Abstract excerpt

Genomic instability is a common feature of cancer etiology. This provides an avenue for therapeutic intervention, since cancer cells are more susceptible than normal cells to DNA damaging agents. However, there is growing evidence that the epigenetic mechanisms that impact DNA methylation and histone status also contribute to genomic instability. The DNA damage response, for example, is modulated by the...

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PMID: 22247744
DOI: 10.1186/1868-7083-3-4

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