Article
Sex chromosomal abnormalities. Etiology, phenotypic expression, and the role of lyonization.
ASHA - 1 Sept 1990
Ho H Z
Abstract excerpt
Individuals with sex chromosomal abnormalities have significantly better chances of leading normal lives than individuals with autosomal abnormalities. This is due, in part, to the role of lyonization in the genetic inactivation of X chromosomes. In contrast to earlier studies contaminated with subject ascertainment bias, prospective studies of individuals with SCA generally indicate a relatively normal profile...
Topics
- Dosage Compensation, Genetic
- Female
- Humans
- Infant, Newborn
- Male
- Phenotype
- Prospective Studies
- Sex Chromosome Aberrations