Direct visualization of affected collagen molecules synthesized by cultured fibroblasts from an osteogenesis imperfecta patient.

Abstract excerpt

Human skin fibroblasts obtained from normal controls and a patient with osteogenesis imperfecta were cultured in the presence of ascorbic acid 2-phosphate, a long-acting vitamin C derivative. Crude collagen samples extracted from the cell layer were made to form lateral aggregates of collagen molecules, segment-long-spacing crystallites. Under the electron microscope, normal and abnormal crystallites of type I...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amino Acid Sequence
• Share to Cells, Cultured