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Article

Direct visualization of affected collagen molecules synthesized by cultured fibroblasts from an osteogenesis imperfecta patient.

Biochemical and biophysical research communications - 15 Oct 1990

Kobayashi K, Hata R, Nagai S, Niwa J, Hoshino T

Abstract excerpt

Human skin fibroblasts obtained from normal controls and a patient with osteogenesis imperfecta were cultured in the presence of ascorbic acid 2-phosphate, a long-acting vitamin C derivative. Crude collagen samples extracted from the cell layer were made to form lateral aggregates of collagen mol...

Topics

Adult
Amino Acid Sequence
Cells, Cultured
Collagen
Female
Fibroblasts
Humans
Infant, Newborn
Male
Microscopy, Electron
Mutation
Osteogenesis Imperfecta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Reference Values

Skin

Source

Identifiers

PMID: 2222471
DOI: 10.1016/s0006-291x(05)80196-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2222471-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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