Article
Elevated inflammatory markers at preschool age precede persistent wheezing at school age.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 May 2012
van de Kant Kim D G, Jansen Maria A, Klaassen Ester M M, van der Grinten Chris P, Rijkers Ger T, Muris Jean W M, van Schayck Onno C P, Jöbsis Quirijn, Dompeling Edward
Abstract excerpt
BACKGROUND: Wheeze is a heterogeneous symptom in preschool children. At preschool age it is hard to predict whether symptoms will pass or persist and develop into asthma. Our objective is to prospectively study whether inflammatory markers in exhaled breath condensate (EBC) and pre- and post-bronchodilator interrupter resistance (Rint) assessed at preschool age, are associated with wheezing phenotypes at school...
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