Article
Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients.
Annals of hepatology - 1 Jan 2000
Nelson David R, Zeuzem Stefan, Andreone Pietro, Ferenci Peter, Herring Robert, Jensen Donald M, Marcellin Patrick, Pockros Paul J, Rodríguez-Torres Maribel, Rossaro Lorenzo, Rustgi Vinod K, Sepe Thomas, Sulkowski Mark, Thomason Isaac R, Yoshida Eric M, Chan Anna, Hill George
Abstract excerpt
INTRODUCTION: Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). This phase 2, double-blind international trial evaluated the optimal treatment regimen of balapiravir plus peginterferon alfa-2a (40KD)/ribavirin. MATERIAL AND METHODS: Treatment-naive genotype 1 patients (N = 516) were randomized to one of seven...
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