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Article

Genetic polymorphism of the human sex hormone-binding globulin: evidence of an isoelectric focusing variant with normal androgen-binding affinities.

Journal of steroid biochemistry - 28 Aug 1990

Larrea F, Oliart R M, Granados J, Mutchinick O, Diaz-Sanchez V, Musto N A

Abstract excerpt

Human sex hormone-binding globulin (hSHBG) is a plasma glycoprotein composed of two identical subunits. The protein, which has high affinity for testosterone and estradiol has been purified to homogeneity. In this study we have investigated, on neuraminidase-treated serum samples, the presence of genetic variations of hSHBG by polyacrylamide gel isoelectric focusing (IEF). Based on IEF analyses of 110 serum...

Topics

Adult
Dihydrotestosterone
Electrophoresis, Polyacrylamide Gel
Gene Frequency
Genetic Variation
Health Status Indicators
Humans
Isoelectric Focusing
Mexico
Neuraminidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pedigree

Phenotype

Polymorphism, Genetic

Sex Hormone-Binding Globulin

Source

Identifiers

PMID: 2214771
DOI: 10.1016/0022-4731(90)90171-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2214771-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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