Article
Acral peeling skin syndrome: a clinically and genetically heterogeneous disorder.
Pediatric dermatology - 1 Jan 2000
Pavlovic Sasha, Krunic Aleksandar L, Bulj Tanja K, Medenica Maria M, Fong Kenneth, Arita Ken, McGrath John A
Abstract excerpt
Acral peeling skin syndrome (APSS) is a rare, autosomal, recessive genodermatosis characterized by painless spontaneous exfoliation of the skin of the hands and feet at a subcorneal or intracorneal level. It usually presents at birth or appears later in childhood or early adulthood. Some cases result from mutations in the TGM5 gene that encodes transglutaminase 5, which has an important role in cross-linking...
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