Article
Polymorphisms of MAMLD1 gene in hypospadias.
Journal of pediatric urology - 1 Dec 2011
Kalfa N, Cassorla F, Audran F, Oulad Abdennabi I, Philibert P, Béroud C, Guys J M, Reynaud R, Alessandrini P, Wagner K, Bréaud J, Valla J S, Morisson Lacombe G, Daures J P, Baskin L, Fukami M, Ogata T, Sultan C
Abstract excerpt
PURPOSE: Mastermind-like domain containing 1 (MAMLD1) is a causative gene for the fetal development of male external genitalia. Almost 10% of patients with both severe and non-severe hypospadias exhibit mutations of MAMLD1. The aim of this work was to determine whether polymorphisms of MAMLD1 are a genetic risk factor for hypospadias. MATERIAL AND METHODS: This study included 150 hypospadias with a range of...
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