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Article

Vemurafenib (PLX4032): an orally available inhibitor of mutated BRAF for the treatment of metastatic melanoma.

The Annals of pharmacotherapy - 1 Nov 2011

Heakal Yasser, Kester Mark, Savage Scott

Abstract excerpt

OBJECTIVE: To summarize the preclinical and clinical data on vemurafenib, approved by the Food and Drug Administration (FDA) on August 17, 2011, and discuss the drug's clinical advantages and limitations. DATA SOURCES: An English-language literature search of MEDLINE/PubMed (1966-August 2011), using the terms PLX4032, RG7204, RO5185426, vemurafenib, and metastatic melanoma, was conducted. In addition, information...

Topics

Antineoplastic Agents
Clinical Trials as Topic
Disease-Free Survival
Drug Evaluation, Preclinical
Humans
Indoles
Melanoma
Mutation
Proto-Oncogene Proteins B-raf
Randomized Controlled Trials as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sulfonamides

Vemurafenib

Source

Identifiers

PMID: 22028422
DOI: 10.1345/aph.1Q363

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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