Article
Critical amino acid residues in proteins: a BioMart integration of Reactome protein annotations with PRIDE mass spectrometry data and COSMIC somatic mutations.
Database : the journal of biological databases and curation - 1 Jan 2011
Ndegwa Nelson, Côté Richard G, Ovelleiro David, D'Eustachio Peter, Hermjakob Henning, Vizcaíno Juan A, Croft David
Abstract excerpt
The reversible phosphorylation of serine, threonine and tyrosine hydroxyl groups is an especially prominent form of post-translational modification (PTM) of proteins. It plays critical roles in the regulation of diverse processes, and mutations that directly or indirectly affect these phosphorylation events have been associated with many cancers and other pathologies. Here, we describe the development of a new...
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