Genetic associations with performance on a behavioral measure of distress intolerance.

doi:10.1016/j.jpsychires.2011.09.017

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Article

Genetic associations with performance on a behavioral measure of distress intolerance.

Journal of psychiatric research - 1 Jan 2012

Amstadter Ananda B, Daughters Stacey B, Macpherson Laura, Reynolds Elizabeth K, Danielson Carla Kmett, Wang Frances, Potenza Marc N, Gelernter Joel, Lejuez C W

Abstract excerpt

Both theory and empirical evidence support possible associations between two candidate genetic polymorphisms (SLC6A4 5-HTTLPR l/s and COMT Val(158)Met--rs4680 variants) and emotion-regulation difficulties. One particular form of emotion-regulation difficulty, distress intolerance, has been measured using a behavioral assessment in youth; data indicate a relationship with poor psychological functioning. No prior...

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PMID: 22024485
DOI: 10.1016/j.jpsychires.2011.09.017
PMCID: PMC3687355

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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