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Article

Clinical severity and quality of life in children and adolescents with Rett syndrome.

Neurology - 15 Nov 2011

Lane J B, Lee H-S, Smith L W, Cheng P, Percy A K, Glaze D G, Neul J L, Motil K J, Barrish J O, Skinner S A, Annese F, McNair L, Graham J, Khwaja O, Barnes K, Krischer J P

Abstract excerpt

OBJECTIVE: The clinical features and genetics of Rett syndrome (RTT) have been well studied, but examination of quality of life (QOL) is limited. This study describes the impact of clinical severity on QOL among female children and adolescents with classic RTT. METHODS: Cross-sectional and longitudinal analyses were conducted on data collected from an NIH-sponsored RTT natural history study. More than 200...

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Source

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Identifiers

PMID: 22013176
DOI: 10.1212/WNL.0b013e3182377dd2
PMCID: PMC3233210

Genes

MECP2

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