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Article

Screening of the ryanodine 1 gene for malignant hyperthermia causative mutations by high resolution melt curve analysis.

Anesthesia and analgesia - 1 Nov 2011

Broman Marcus, Heinecke Kai, Islander Gunilla, Schuster Frank, Glahn Klaus, Bodelsson Mikael, Treves Susan, Müller Clemens

Abstract excerpt

BACKGROUND: A diagnosis of malignant hyperthermia (MH) can be determined by performing an in vitro (muscle) contracture test (IVCT) or by identifying a known MH causative mutation in the ryanodine receptor 1 gene (RYR1). Genetic diagnosis has an advantage over IVCT because it is less invasive. Direct sequencing of the very large RYR1 coding region (15.117 bases) is a laborious and expensive task. In this study,...

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Source

Identifiers

PMID: 21965348
DOI: 10.1213/ANE.0b013e318228293e

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Screening of the ryanodine 1 gene for malignant hyperthermia causative mutations by high resolution melt curve analysis.PMID 21965348Read ↗

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