Article
A model of canine leukocyte telomere dynamics.
Aging cell - 1 Dec 2011
Benetos Athanase, Kimura Masayuki, Labat Carlos, Buchoff Gerald M, Huber Shell, Labat Laura, Lu Xiaobin, Aviv Abraham
Abstract excerpt
Recent studies have found associations of leukocyte telomere length (TL) with diseases of aging and with longevity. However, it is unknown whether birth leukocyte TL or its age-dependent attrition--the two factors that determine leukocyte TL dynamics--explains these associations because acquiring this information entails monitoring individuals over their entire life course. We tested in dogs a model of leukocyte...
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