Unraveling the Human Bone Microenvironment beyond the Classical Extracellular Matrix Proteins: A Human Bone Protein Library

Abstract excerpt

A characteristic feature of bone, differentiating it from other connective tissues, is the mineralized extracellular matrix (ECM). Mineral accounts for the majority of the bone tissue volume, being the remainder organic material mostly derived from collagen. This, and the fact that only a limited number of noncollagenous ECM proteins are described, provides a limited view of the bone tissue composition and bone...

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