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Article

A phase I trial of liposomal doxorubicin, bevacizumab, and temsirolimus in patients with advanced gynecologic and breast malignancies.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2011

Moroney John W, Schlumbrecht Matthew P, Helgason Thorunn, Coleman Robert L, Moulder Stacy, Naing Aung, Bodurka Diane C, Janku Filip, Hong David S, Kurzrock Razelle

Abstract excerpt

PURPOSE: Liposomal doxorubicin (D) and bevacizumab (A) are active single agents in gynecologic and breast malignancies which share a resistance mechanism: upregulation of hypoxia inducible factor (HIF-1α). We, therefore, added temsirolimus (T), which inhibits HIF-1α, to D and A (DAT). Trial objectives were assessment of safety, preliminary efficacy, and identification of biological response correlates. PATIENTS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

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Source

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Identifiers

PMID: 21890452
DOI: 10.1158/1078-0432.CCR-11-0666
PMCID: PMC3207033

Genes

PTEN
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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