Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Neonatal atrial tachycardia: suggestive clinical sign of Costello syndrome].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie - 1 Oct 2011

Laux D, Bajolle F, Maltret A, Bonnet D

Abstract excerpt

Costello syndrome is a rare association of symptoms caused by de novo germline mutations of the HRAS oncogene interfering in the RAS/mitogen-activated protein kinase (MAPK) signal transduction pathway. Mutations in this pathway are also responsible for Noonan syndrome and the related cardiofaciocutaneous syndrome (CFC) as well as LEOPARD syndrome. The 4 syndromes share phenotypic resemblances concerning patients'...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Multiple
Share to Biomarkers
Share to Costello Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diagnosis, Differential

Share to Infant, Newborn

Share to Mitogen-Activated Protein Kinases

Share to ras Proteins

Share to Signal Transduction

Source

Identifiers

PMID: 21885263
DOI: 10.1016/j.arcped.2011.07.010

Genes

HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Neonatal atrial tachycardia: suggestive clinical sign of Costello syndrome].PMID 21885263Read ↗

Clinical, pathological, and molecular analyses of cardiovascular abnormalities in Costello syndrome: A Ras/MAPK pathway syndromeSemantic proximity Read ↗

Costello syndrome: clinical diagnosis in the first year of life.Semantic proximity Read ↗

Costello syndrome and related disorders.Semantic proximity Read ↗

Perinatal features of the RASopathies: Noonan syndrome, cardiofaciocutaneous syndrome and Costello syndrome.Semantic proximity Read ↗

Phenotypic and Genetic Characteristics of Five Korean Patients with Costello Syndrome.Semantic proximity Read ↗

[Prenatal hypertrophic cardiomyopathy and neonatal noonan syndrome: an association to remember].Semantic proximity Read ↗

Ventricular arrhythmia and Noonan Syndrome with LZTR1 Mutations: Expanding the Phenotype with a Case Report and Review of the LiteratureSemantic proximity Read ↗

[A pathogenic variation of HRAS gene causing Costello syndrome: a Ras/MAPK pathway syndrome].Semantic proximity Read ↗

Expanding the phenotype of Timothy syndrome type 2: an adolescent with ventricular fibrillation but normal development.Semantic proximity Read ↗

Atypical, severe hypertrophic cardiomyopathy in a newborn presenting Noonan syndrome harboring a recurrent heterozygous MRAS variant.Semantic proximity Read ↗

Severe Lymphatic Disorder and Multifocal Atrial Tachycardia Treated with Trametinib in a Patient with Noonan Syndrome and SOS1 Mutation.Semantic proximity Read ↗

The rare Costello variant HRAS c.173C>T (p.T58I) with severe neonatal hypertrophic cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.