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Article

Folinic acid supplementation in Rett syndrome patients does not influence the course of the disease: a randomized study.

Journal of child neurology - 1 Mar 2012

Hagebeuk Eveline E O, Duran Marinus, Koelman Johannes H T M, Abeling Nicolaas G G M, Vyth Arno, Poll-The Bwee-Tien

Abstract excerpt

Rett syndrome is a neurodevelopmental disorder in girls, related to mutations in MECP2 gene. It has been postulated that low 5-methyltetrahydrofolate (5-MTHF) levels are present in cerebrospinal fluid. Folinic acid demonstrated clinical improvement. However, because studies have produced conflicting results, we performed a randomized, double-blind crossover, long-term, follow-up study on folinic acid. Eight Rett...

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Identifiers

PMID: 21868372
DOI: 10.1177/0883073811417184

Genes

MECP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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