Article
IPNV with high and low virulence: host immune responses and viral mutations during infection.
Virology journal - 10 Aug 2011
Skjesol Astrid, Skjæveland Ingrid, Elnæs Marianne, Timmerhaus Gerrit, Fredriksen Børge N, Jørgensen Sven Martin, Krasnov Aleksei, Jørgensen Jorunn B
Abstract excerpt
BACKGROUND: Infectious pancreatic necrosis virus (IPNV) is an aquatic member of the Birnaviridae family that causes widespread disease in salmonids. IPNV is represented by multiple strains with markedly different virulence. Comparison of isolates reveals hyper variable regions (HVR), which are presumably associated with pathogenicity. However little is known about the rates and modes of sequence divergence and...
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