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Article

Late-onset lower motor neuronopathy: a new autosomal dominant disorder.

Neurology - 26 Jul 2011

Jokela M, Penttilä S, Huovinen S, Hackman P, Saukkonen A M, Toivanen J, Udd B

Abstract excerpt

OBJECTIVE: Characterization of a new type of late-onset autosomal dominant lower motor neuron disease. METHODS: Patients from 2 families underwent detailed neurologic, electrophysiologic, muscle biopsy, and laboratory investigations. MRI of lower limbs was performed in selected patients. DNA samples from leukocytes were used for molecular genetic linkage studies. RESULTS: First symptoms were muscle cramps and...

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PMID: 21715705
DOI: 10.1212/WNL.0b013e3182267b71

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