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Article

<i>STAT1</i> Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis

29 Jun 2011

Abstract excerpt

BACKGROUND: Chronic mucocutaneous candidiasis (CMC) is characterized by susceptibility to candida infection of skin, nails, and mucous membranes. Patients with recessive CMC and autoimmunity have mutations in the autoimmune regulator AIRE. The cause of autosomal dominant CMC is unknown. METHODS: We evaluated 14 patients from five families with autosomal dominant CMC. We incubated their peripheral-blood...

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PMID: 21714643
DOI: 10.1056/nejmoa1100102

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