Article
Enhanced frequency of CFTR gene variants in couples who are candidates for assisted reproductive technology treatment.
Clinical chemistry and laboratory medicine - 1 Aug 2011
Tomaiuolo Rossella, Fausto Marsia, Elce Ausilia, Strina Ida, Ranieri Antonio, Amato Felice, Castaldo Giuseppe, De Placido Giuseppe, Alviggi Carlo
Abstract excerpt
BACKGROUND: An increased frequency of (cystic fibrosis transmembrane conductance regulator) CFTR mutations has been detected in some types of male infertility. The aim of this study was to shed light on the link between CFTR mutations and infertility. METHODS: We sequenced the CFTR gene in 294 subjects (190 males) affected by infertility of different origin who underwent assisted reproductive technology (ART). As...
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