No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder.

doi:10.1002/ajmg.b.31201

Article

No association between a common single nucleotide polymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2011

Curran Sarah, Bolton Patrick, Rozsnyai Kinga, Chiocchetti Andreas, Klauck Sabine M, Duketis Eftichia, Poustka Fritz, Schlitt Sabine, Freitag Christine M, Lee Irene, Muglia Pierandrea, Poot Martin, Staal Wouter, de Jonge Maretha V, Ophoff Roel A, Lewis Cathryn, Skuse David, Mandy Will, Vassos Evangelos, Fossdal Ragnheidur, Magnusson Páll, Hreidarsson Stefan, Saemundsen Evald, Stefansson Hreinn, Stefansson Kari, Collier David

Abstract excerpt

The Autism Genome Project (AGP) Consortium recently reported genome-wide significant association between autism and an intronic single nucleotide polymorphism marker, rs4141463, within the MACROD2 gene. In the present study we attempted to replicate this finding using an independent case-control design of 1,170 cases with autism spectrum disorder (ASD) (874 of which fulfilled narrow criteria for Autism (A)) from...

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