Critical comments for roles of biomarkers in the diagnosis and treatment of cancer.

Abstract excerpt

A biomarker is defined as "a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic/pharmacodynamic responses to a therapeutic intervention". Various assays, including immunohistochemistry, gene constitution such as amplification, mutation, and rearrangement, gene and protein expression analysis such as single gene or protein...

Topics

• Antineoplastic Agents
• Biomarkers, Tumor
• Gene Expression
• Humans
• Molecular Targeted Therapy
• Mutation
• Neoplasms
• Prognosis
• Randomized Controlled Trials as Topic