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Article

Arylsulfatase a gene polymorphisms in relapsing remitting multiple sclerosis: genotype-phenotype correlation and estimation of disease progression.

Collegium antropologicum - 1 Jan 2011

Baronica Koraljka Bacić, Mlinac Kristina, Ozretić David, Vladić Anton, Bognar Svjetlana Kalanj

Abstract excerpt

Arylsulfatase A (ASA) is a lysosomal enzyme involved in catabolism of cerebroside-sulfate, major lipid constituent of oligodendrocyte membranes. Various polymorphisms in ASA gene have been described, leading to different levels of enzyme deficiency. Progressive demyelination occurs in metachromatic leukodystrophy (MLD), while the condition of ASA-pseudodeficiency (ASA-PD) is suggested to contribute to complex...

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PMID: 21648305

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