Article
Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia.
Journal of experimental & clinical cancer research : CR - 1 Jun 2011
Skoczen Szymon, Tomasik Przemyslaw J, Bik-Multanowski Miroslaw, Surmiak Marcin, Balwierz Walentyna, Pietrzyk Jacek J, Sztefko Krystyna, Gozdzik Jolanta, Galicka-Latała Danuta, Strojny Wojciech
Abstract excerpt
BACKGROUND: Approximately 20% of children and adolescents in Europe are overweight. Survivors of pediatric acute lymphoblastic leukemia (ALL) are at increased risk of overweight and obesity. The purpose of this study was to assess leptin and leptin soluble receptor levels, as well as polymorphisms of selected genes in survivors of pediatric ALL, and the influence of chemo- and radiotherapy on development of...
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