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Article

Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature.

Genetics - 1 Aug 2011

Roux Fabrice, Colomé-Tatché Maria, Edelist Cécile, Wardenaar René, Guerche Philippe, Hospital Frédéric, Colot Vincent, Jansen Ritsert C, Johannes Frank

Abstract excerpt

We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally...

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Identifiers

PMID: 21596900
DOI: 10.1534/genetics.111.128744
PMCID: PMC3176100

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