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Article

Distribution of the phenotypic effects of random homologous recombination between two virus species.

PLoS pathogens - 1 May 2011

Vuillaume Florence, Thébaud Gaël, Urbino Cica, Forfert Nadège, Granier Martine, Froissart Rémy, Blanc Stéphane, Peterschmitt Michel

Abstract excerpt

Recombination has an evident impact on virus evolution and emergence of new pathotypes, and has generated an immense literature. However, the distribution of phenotypic effects caused by genome-wide random homologous recombination has never been formally investigated. Previous data on the subject have promoted the implicit view that most viral recombinant genomes are likely to be deleterious or lethal if the...

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PMID: 21573141
DOI: 10.1371/journal.ppat.1002028
PMCID: PMC3088723

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