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Article

Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability.

Nucleic acids research - 1 Aug 2011

Díaz de la Loza María Del Carmen, Gallardo Mercedes, García-Rubio María Luisa, Izquierdo Alicia, Herrero Enrique, Aguilera Andrés, Wellinger Ralf Erik

Abstract excerpt

Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron-sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron-sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron...

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Identifiers

PMID: 21511814
DOI: 10.1093/nar/gkr193
PMCID: PMC3152343

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Source receipt: pubmed, retrieved 7 Sept 2026.

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