Article
Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability.
Nucleic acids research - 1 Aug 2011
Díaz de la Loza María Del Carmen, Gallardo Mercedes, García-Rubio María Luisa, Izquierdo Alicia, Herrero Enrique, Aguilera Andrés, Wellinger Ralf Erik
Abstract excerpt
Genomic instability is related to a wide-range of human diseases. Here, we show that mitochondrial iron-sulfur cluster biosynthesis is important for the maintenance of nuclear genome stability in Saccharomyces cerevisiae. Cells lacking the mitochondrial chaperone Zim17 (Tim15/Hep1), a component of the iron-sulfur biosynthesis machinery, have limited respiration activity, mimic the metabolic response to iron...
Topics
- Cell Nucleus
- DNA Damage
- DNA Replication
- Gene Deletion
- Gene Expression Regulation, Fungal
- Genomic Instability
- Iron
- Iron-Sulfur Proteins
- Mitochondrial Proteins
- Mutation
- Recombinases
- Recombination, Genetic
- Replication Protein C