A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings.

doi:10.1016/j.biopsych.2011.01.040

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Article

A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings.

Biological psychiatry - 1 Aug 2011

Sonuga-Barke Edmund J S, Kumsta Robert, Schlotz Wolff, Lasky-Su Jessica, Marco Rafaela, Miranda Ana, Mulas Fernando, Oades Robert D, Banaschewski Tobias, Mueller Ueli, Andreou Penny, Christiansen Hanna, Gabriels Isabel, Uebel Henrik, Kuntsi Jonna, Franke Barbara, Buitelaar Jan, Ebstein Richard, Gill Michael, Anney Richard, Roeyers Herbert, Rothenberger Aribert, Sergeant Joseph, Steinhausen Hans Christoph, Asherson Philip, Faraone Stephen V

Abstract excerpt

BACKGROUND: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with dopamine regulating genes and delay aversion would be associated with serotonin-regulating genes. METHODS: Impulsive drive for immediate reward and delay...

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PMID: 21497794
DOI: 10.1016/j.biopsych.2011.01.040
PMCID: PMC3134592

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