Article
Sox-9 facilitates differentiation of adipose tissue-derived stem cells into a chondrocyte-like phenotype in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Aug 2011
Yang Zhe, Huang Chun-Yuh Charles, Candiotti Keith A, Zeng Xiaoling, Yuan Taiyi, Li Jinliang, Yu Hong, Abdi Salahadin
Abstract excerpt
The purpose of this study is to test whether ectopic expression of Sox-9 can induce adipose tissue-derived stem cells (ASCs) to function as real nucleus pulposus (NP) cells in vitro. Adenoviral vectors expressing Sox-9 were reported to infect the chondroblastic and human disc cells, which resulted in increased Sox-9 and type II collagen production. ASCs were isolated from rat inguinal adipose pad, characterized,...
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