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Article

A new method for FMR1 gene methylation screening by multiplex methylation-specific real-time polymerase chain reaction.

Genetic testing and molecular biomarkers - 1 Jun 2011

Elias Marjanu Hikmah, Ankathil Ravindran, Salmi Abdul Razak, Sudhikaran Wanna, Limprasert Pornprot, Zilfalil Bin Alwi

Abstract excerpt

Fragile X Syndrome (FXS) is the most common form of inherited mental retardation in men. It is caused by abnormalities in the FMR1 gene that are associated with CGG repeat expansion and the hypermethylation status of its promoter. Methylated alleles lead to transcriptional inhibition and consequent loss of Fragile X Mental Retardation Protein. Chemical modification of cytosine to uracil by bisulfite treatment has...

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Identifiers

PMID: 21329465
DOI: 10.1089/gtmb.2010.0191

Genes

FMR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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