Article
Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness.
The American journal of psychiatry - 1 Apr 2011
Ingason Andrés, Kirov George, Giegling Ina, Hansen Thomas, Isles Anthony R, Jakobsen Klaus D, Kristinsson Kari T, le Roux Louise, Gustafsson Omar, Craddock Nick, Möller Hans-Jürgen, McQuillin Andrew, Muglia Pierandrea, Cichon Sven, Rietschel Marcella, Ophoff Roel A, Djurovic Srdjan, Andreassen Ole A, Pietiläinen Olli P H, Peltonen Leena, Dempster Emma, Collier David A, St Clair David, Rasmussen Henrik B, Glenthøj Birte Y, Kiemeney Lambertus A, Franke Barbara, Tosato Sarah, Bonetto Chiara, Saemundsen Evald, Hreidarsson Stefán J, Nöthen Markus M, Gurling Hugh, O'Donovan Michael C, Owen Michael J, Sigurdsson Engilbert, Petursson Hannes, Stefansson Hreinn, Rujescu Dan, Stefansson Kari, Werge Thomas
Abstract excerpt
OBJECTIVE: Rare copy number variants have been implicated in different neurodevelopmental disorders, with the same copy number variants often increasing risk of more than one of these phenotypes. In a discovery sample of 22 schizophrenia patients with an early onset of illness (10-15 years of age), the authors observed in one patient a maternally derived 15q11-q13 duplication overlapping the Prader-Willi/Angelman...
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