Article
Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study.
PloS one - 2 Feb 2011
Lee Kyung-Tai, Byun Mi-Jeong, Kang Kyung-Soo, Park Eung-Woo, Lee Seung-Hwan, Cho Seoae, Kim Hyoyoung, Kim Kyu-Won, Lee Taeheon, Park Jong-Eun, Park Woncheoul, Shin Donghyun, Park Hong-Seog, Jeon Jin-Tae, Choi Bong-Hwan, Jang Gul-Won, Choi Sang-Haeng, Kim Dae-Won, Lim Dajeong, Park Hae-Suk, Park Mi-Rim, Ott Jurg, Schook Lawrence B, Kim Tae-Hun, Kim Heebal
Abstract excerpt
Obesity represents a major global public health problem that increases the risk for cardiovascular or metabolic disease. The pigs represent an exceptional biomedical model related to energy metabolism and obesity in humans. To pinpoint causal genetic factors for a common form of obesity, we conducted local genomic de novo sequencing, 18.2 Mb, of a porcine QTL region affecting fatness traits, and carried out SNP...
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