Article
Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2011
Donev Ivan S, Wang Wei, Yamada Tadaaki, Li Qi, Takeuchi Shinji, Matsumoto Kunio, Yamori Takao, Nishioka Yasuhiko, Sone Saburo, Yano Seiji
Abstract excerpt
PURPOSE: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as gefitinib and erlotinib, show favorable response to EGFR mutant lung cancer. However, the responders acquire resistance almost without exception. We recently reported that hepatocyte growth factor (HGF) ind...
Topics
- Animals
- Apoptosis
- Blotting, Western
- Cell Line
- Cell Line, Tumor
- Cell Proliferation
- Cell Survival
- Drug Resistance, Neoplasm
- ErbB Receptors
- Erlotinib Hydrochloride
- Female
- Furans
- Gefitinib
- Hepatocyte Growth Factor