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Article

Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2011

Donev Ivan S, Wang Wei, Yamada Tadaaki, Li Qi, Takeuchi Shinji, Matsumoto Kunio, Yamori Takao, Nishioka Yasuhiko, Sone Saburo, Yano Seiji

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as gefitinib and erlotinib, show favorable response to EGFR mutant lung cancer. However, the responders acquire resistance almost without exception. We recently reported that hepatocyte growth factor (HGF) induces EGFR-TKI resistance by activating MET that restores downstream mitogen activated protein kinase...

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Identifiers

PMID: 21220474
DOI: 10.1158/1078-0432.CCR-10-1993

Genes

EGFR
HGF
MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.PMID 21220474Read ↗

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