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Article

Genetic linkage analyses and Cx50 mutation detection in a large multiplex Chinese family with hereditary nuclear cataract.

Ophthalmic genetics - 1 Mar 2011

He Wei, Li Xin, Chen Jiajing, Xu Ling, Zhang Feng, Dai Qiushi, Cui Hao, Wang Duen-Mei, Yu Jun, Hu Songnian, Lu Shan

Abstract excerpt

PURPOSE: The aim of the study was to characterize the underlying mutation in a large multiplex Chinese family with hereditary nuclear cataract. METHODS: A 6-generation Chinese family having hereditary nuclear cataract was recruited and clinically verified. Blood DNA samples were obtained from 53 available family members. Linkage analyses were performed on the known candidate regions for hereditary cataract with...

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PMID: 21174522
DOI: 10.3109/13816810.2010.535886

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