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Article

Exploring the influence of torsinA expression on protein quality control.

Neurochemical research - 1 Mar 2011

Gordon Kara L, Glenn Kevin A, Gonzalez-Alegre Pedro

Abstract excerpt

DYT1 dystonia is caused by a glutamic acid deletion (ΔE) in the endoplasmic reticulum (ER) protein torsinA. Previous studies suggest that torsinA modulates the aggregation of cytosolic misfolded proteins and ER stress responses, although the mechanisms underlying those effects remain unclear. In order to investigate the bases of these observations, we analyzed the interaction between torsinA expression, protein...

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PMID: 21161590
DOI: 10.1007/s11064-010-0363-4

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Exploring the influence of torsinA expression on protein quality control.PMID 21161590Read ↗

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Inhibition of N-linked glycosylation prevents inclusion formation by the dystonia-related mutant form of torsinA.Semantic proximity Read ↗

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