Article
Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome.
Proceedings of the National Academy of Sciences of the United States of America - 14 Dec 2010
Cockram James, White Jon, Zuluaga Diana L, Smith David, Comadran Jordi, Macaulay Malcolm, Luo Zewei, Kearsey Mike J, Werner Peter, Harrap David, Tapsell Chris, Liu Hui, Hedley Peter E, Stein Nils, Schulte Daniela, Steuernagel Burkhard, Marshall David F, Thomas William T B, Ramsay Luke, Mackay Ian, Balding David J, Waugh Robbie, O'Sullivan Donal M
Abstract excerpt
Although commonplace in human disease genetics, genome-wide association (GWA) studies have only relatively recently been applied to plants. Using 32 phenotypes in the inbreeding crop barley, we report GWA mapping of 15 morphological traits across ∼500 cultivars genotyped with 1,536 SNPs. In contrast to the majority of human GWA studies, we observe high levels of linkage disequilibrium within and between...
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