A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.

doi:10.1038/348651a0

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Article

A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.

Nature - 13 Dec 1990

Goto Y, Nonaka I, Horai S

Abstract excerpt

Mitochondrial encephalomyopathies are usually divided into three distinct clinical subgroups: (1) mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS); (2) myoclonus epilepsy associated with ragged-red fibres (MERRF); and (3) chronic progressive external ophtha...

Topics

Base Sequence
Brain Diseases
Humans
Male
Mitochondria, Muscle
Molecular Sequence Data
Mutation
RNA, Transfer, Leu
Reference Values
Restriction Mapping
Sequence Homology, Nucleic Acid

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