Article
Primary resistance to maraviroc in a large set of R5-V3 viral sequences from HIV-1-infected patients.
The Journal of antimicrobial chemotherapy - 1 Dec 2010
Seclén Eduardo, González María del Mar, Lapaz Mariana, Rodríguez Carmen, del Romero Jorge, Aguilera Antonio, de Mendoza Carmen, Soriano Vincent, Poveda Eva
Abstract excerpt
OBJECTIVES: Evaluation of the prevalence of V3 mutational patterns associated with maraviroc resistance in R5-using variants. METHODS: V3 sequences were obtained from 809 plasma specimens collected from maraviroc-naive HIV-1-infected individuals on regular follow-up at Hospital Carlos III. Sequences considered to harbour R5-tropic viruses were examined for the presence of primary maraviroc resistance mutational...
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