Article
Immunosuppression and renal outcome in congenital and pediatric steroid-resistant nephrotic syndrome.
Clinical journal of the American Society of Nephrology : CJASN - 1 Nov 2010
Büscher Anja K, Kranz Birgitta, Büscher Rainer, Hildebrandt Friedhelm, Dworniczak Bernd, Pennekamp Petra, Kuwertz-Bröking Eberhard, Wingen Anne-Margret, John Ulrike, Kemper Markus, Monnens Leo, Hoyer Peter F, Weber Stefanie, Konrad Martin
Abstract excerpt
BACKGROUND AND OBJECTIVES: Mutations in podocyte genes are associated with steroid-resistant nephrotic syndrome (SRNS), mostly affecting younger age groups. To date, it is unclear whether these patients benefit from intensified immunosuppression with cyclosporine A (CsA). The aim of this study was to evaluate the influence of podocyte gene defects in congenital nephrotic syndrome (CNS) and pediatric SRNS on the...
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