Article
Low frequency of common LRRK2 mutations in Mexican patients with Parkinson's disease.
Neuroscience letters - 19 Nov 2010
Yescas Petra, López Marisol, Monroy Nancy, Boll Marie-Catherine, Rodríguez-Violante Mayela, Rodríguez Ulises, Ochoa Adriana, Alonso María Elisa
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 gene (LRRK2) account for as much as 5-6% of familial Parkinson's disease (PD) and 1-2% of sporadic PD. These mutations represent the most frequent cause of autosomal dominant PD, particularly in certain ethnic groups. In this first report concerning LRRK2...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Mexico
- Middle Aged
- Mutation
- Parkinson Disease
- Pedigree
- Protein Serine-Threonine Kinases
- Young Adult