Article
Early life programming and neurodevelopmental disorders.
Biological psychiatry - 15 Aug 2010
Bale Tracy L, Baram Tallie Z, Brown Alan S, Goldstein Jill M, Insel Thomas R, McCarthy Margaret M, Nemeroff Charles B, Reyes Teresa M, Simerly Richard B, Susser Ezra S, Nestler Eric J
Abstract excerpt
For more than a century, clinical investigators have focused on early life as a source of adult psychopathology. Early theories about psychic conflict and toxic parenting have been replaced by more recent formulations of complex interactions of genes and environment. Although the hypothesized mechanisms have evolved, a central notion remains: early life is a period of unique sensitivity during which experience...
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