Article
Deletion of chromosome 21 and normal intelligence: molecular definition of the lesion.
Human genetics - 1 Jun 1991
Korenberg J R, Kalousek D K, Anneren G, Pulst S M, Hall J G, Epstein C J, Cox D R
Abstract excerpt
Application of a method for the fine structure analysis of unbalanced chromosomal rearrangements using quantitative Southern blot analysis has established that an individual of normal intelligence and largely normal appearance has a significant interstitial deletion of chromosome 21. Using high resolution cytogenetic analysis and molecular analysis with five single copy DNA sequences unique to chromosome 21 and a...
Topics
- Blotting, Southern
- Cells, Cultured
- Child
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- DNA Probes
- Gene Rearrangement
- Humans
- In Vitro Techniques
- Intelligence