Article
Tobacco use increase the number of aneuploid nuclei in the clinically healthy oral epithelium
2 Jul 2010
Abstract excerpt
BACKGROUND: The most important risk factor linked to the development of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) is tobacco use. Tobacco contains carcinogens that influence the DNA repair, cell cycle control and may produce chromosomal aberrations. The loss or acquisition of one or more chromosomes is defined as aneuploidy. METHODS: Aneuploidy was determined by means of the DNA-content...
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