Article
Pharmacodynamics of PEG-IFN-alpha-2a in HIV/HCV co-infected patients: implications for treatment outcomes.
Journal of hepatology - 1 Sept 2010
Dahari Harel, Affonso de Araujo Evaldo S, Haagmans Bart L, Layden Thomas J, Cotler Scott J, Barone Antonio A, Neumann Avidan U
Abstract excerpt
BACKGROUND & AIMS: The pharmacokinetics and pharmacodynamics of pegylated-interferon-alpha-2a (PEG-IFN) have not been described in HCV/HIV co-infected patients. We sought to estimate the pharmacokinetics and pharmacodynamics of PEG-IFN and determine whether these parameters predict treatment outcome. METHODS: Twenty-six HCV/human immunodeficiency virus (HIV)-co-infected patients were treated with a 48-week...
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