Article
Partial epilepsy with antecedent febrile seizures and seizure aggravation by antiepileptic drugs: associated with loss of function of Na(v) 1.1.
Epilepsia - 1 Sept 2010
Liao Wei-Ping, Shi Yi-Wu, Long Yue-Sheng, Zeng Yang, Li Tian, Yu Mei-Juan, Su Tao, Deng Ping, Lei Zhi-Gang, Xu Shu-Jun, Deng Wei-Yi, Liu Xiao-Rong, Sun Wei-Wen, Yi Yong-Hong, Xu Zao C, Duan Shumin
Abstract excerpt
PURPOSE: Generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy in infancy (SMEI) are associated with sodium channel α-subunit type-1 gene (SCN1A) mutations. Febrile seizures and partial seizures occur in both GEFS+ and SMEI; sporadic onset and seizure aggravation by antiepileptic drugs (AEDs) are features of SMEI. We thus searched gene mutations in isolated cases of partial...
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