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Partial epilepsy with antecedent febrile seizures and seizure aggravation by antiepileptic drugs: associated with loss of function of Na(v) 1.1.

Epilepsia - 1 Sept 2010

Liao Wei-Ping, Shi Yi-Wu, Long Yue-Sheng, Zeng Yang, Li Tian, Yu Mei-Juan, Su Tao, Deng Ping, Lei Zhi-Gang, Xu Shu-Jun, Deng Wei-Yi, Liu Xiao-Rong, Sun Wei-Wen, Yi Yong-Hong, Xu Zao C, Duan Shumin

Abstract excerpt

PURPOSE: Generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy in infancy (SMEI) are associated with sodium channel α-subunit type-1 gene (SCN1A) mutations. Febrile seizures and partial seizures occur in both GEFS+ and SMEI; sporadic onset and seizure aggravation by antiepileptic drugs (AEDs) are features of SMEI. We thus searched gene mutations in isolated cases of partial...

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Anticonvulsants
Channelopathies
Epilepsies, Myoclonic
Epilepsies, Partial
Epilepsy, Generalized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NAV1.2 Voltage-Gated Sodium Channel

Seizures, Febrile

Sodium Channel Blockers

Source

Identifiers

PMID: 20550552
DOI: 10.1111/j.1528-1167.2010.02645.x

Genes

GABRG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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