Article
Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2010
Willeit Peter, Willeit Johann, Brandstätter Anita, Ehrlenbach Silvia, Mayr Agnes, Gasperi Arno, Weger Siegfried, Oberhollenzer Friedrich, Reindl Markus, Kronenberg Florian, Kiechl Stefan
Abstract excerpt
OBJECTIVE: To determine the association between leukocyte telomere length (TL) and atherosclerosis and its clinical sequelae stroke and myocardial infarction. METHODS AND RESULTS: Within the scope of the prospective population-based Bruneck Study, leukocyte TL was measured by quantitative polymerase chain reaction in 800 women and men aged 45 to 84 years (in 1995). The manifestation of cardiovascular disease...
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