[Clinical pharmacogenetics in the treatment of schizophrenia].

Abstract excerpt

Numerous investigations on metabolic enzymes, cytochrome P450 (CYP) have been conducted since 1990. In the psychiatric field, CYP2D6, which is a major enzyme involved in the metabolism of antidepressants and antipsychotics, has been focused on. Poor metabolizers (deficit metabolizers) for CYP2D6 are 7% in Caucasians, while they are less than 1% in Asians. Frequency of a mutated allele for CYP2D6*10, which leads...

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